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Most GLP-1 agonists do not require dose adjustment for mild to moderate renal impairment, though specific agents have varying recommendations for severe impairment

10.1016/j.ejphar.2011.11.005 100 LiT.JiaoJ

Underlining the translatability of findings to the human disease condition, a downregulation of the ketogenesis pathway, as expected by a drop in HMGCS2 expression, has been described for colonocytes of CD patients (35) and in line, reduced levels of the ketone body -hydroxybutyrate were observed in the colonic mucosa of IBD patients which correlated with IBD activity index (99)

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